Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients

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Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients.

Porphyromonas gingivalis gingipains is suspected to be one of the most important causative agents of periodontitis. We postulated that the inhibition of gingipains may reduce the pathogenic nature of P. gingivalis. Anti-P. gingivalis egg yolk antibody (IgY-GP) was isolated from the yolks of hens immunized with purified gingipains. We applied IgY-GP gel subgingivally in periodontitis patients wh...

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Antibody Titer Against Porphyromonas Gingivalis in Rats with Experimentally Induced Periodontitis

Background and Aim: This study aimed to assess the antibody titer against Porphyromonas gingivalis (P. gingivalis) in rats with experimentally induced periodontitis. Materials and Methods: Thirty-three Surrey rats were randomly divided into three groups (n=11). Group 1 was vaccinated with formalin-killed whole cell (FKWC) P. gingivalis with incomplete Freund's adjuvant as vaccine carrier and o...

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Periodontitis and Porphyromonas gingivalis in Preclinical Stage of Arthritis Patients

PURPOSE To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naïve preclinical stage of arthritis patients. METHODS We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti-rheumatic drugs o...

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Antibody Responses to Arg-gingipain of Porphyromonas gingivalis in Periodontitis Patients

Arginine-specific cysteine proteinase (Arg-gingipain: Rgp) produced by Porphyromonas gingivalis is a major virulence factor of this periodontal pathogen, which is thought to play an important role in periodontitis by interrupting host defense mechanisms and by participating in the penetration and destruction of host connective tissues. We studied the IgG response against Rgp A components in pat...

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Gingipains as candidate antigens for Porphyromonas gingivalis vaccine.

Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Argi...

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ژورنال

عنوان ژورنال: Journal of Oral Science

سال: 2007

ISSN: 1880-4926,1343-4934

DOI: 10.2334/josnusd.49.201